The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the HEAL Initiative, specifically targeting the NIH-DOD-VA Pain Management Collaboratory to support pragmatic and implementation science demonstration projects. This funding opportunity aims to solicit UG3/UH3 phased cooperative agreement research applications focused on nonopioid pain management strategies and the prevention and treatment of opioid misuse among U.S. Veterans, military personnel, and their families. The initiative emphasizes the importance of large-scale clinical trials and the integration of complementary and integrative approaches alongside standard care. The estimated total program funding is $850,000, with one award expected, and the NOFO is anticipated to be published in Fall 2024, with applications due in November 2024. For further details, interested applicants should prepare to engage in meaningful collaborations as the application process approaches.