HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
ID: 347797Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $2M

Eligible Applicants

Others

Funding Category

Income Security and Social Services

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/347797

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-028.html
Timeline
    Description

    The National Institutes of Health (NIH) is inviting proposals for the HEAL Initiative, aimed at researching the mechanisms of pain relief through FDA-approved medical devices. This funding opportunity seeks interdisciplinary teams of multiple principal investigators to collaborate on complex research projects that optimize the efficacy of devices such as spinal cord stimulation and transcutaneous electrical nerve stimulation, addressing the urgent need for alternative pain management solutions amid the ongoing opioid crisis. The initiative emphasizes innovation in pain management strategies and understanding pain relief mechanisms, with eligibility extended to various higher education institutions, nonprofits, and for-profit organizations. Interested applicants should note that the deadline for submission is June 10, 2025, with a funding ceiling of $1.5 million, and can direct inquiries to grantsinfo@nih.gov for further information.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-NS-23-028-Full-Announcement.html
    RFA-NS-23-028.html
    The Department of Health and Human Services, through the NIH, is soliciting proposals for the HEAL Initiative to research the mechanisms of action of pain relief via FDA-approved medical devices. The initiative addresses the urgent need for alternative pain management solutions amid the opioid crisis affecting millions of Americans. The funding opportunity (NOFO) seeks interdisciplinary teams with multiple principal investigators to collaborate on complex research projects aimed at optimizing the efficacy of these devices like spinal cord stimulation and transcutaneous electrical nerve stimulation. Applications can encompass clinical trials or mechanistic studies, but projects focused on non-FDA approved devices or primarily on clinical efficacy are excluded. The overall goal is to foster innovation, improve pain management strategies, and significantly advance understanding of pain relief mechanisms while ensuring diverse team composition and effective management plans. Eligibility is open to various higher education institutions, nonprofits, and for-profit organizations. The deadline for submission is June 10, 2025, with an emphasis on detailed project timelines and benchmarks to evaluate success.
    Similar Opportunities
    HEAL Initiative: Translational Development of Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative for the development of clinical-grade diagnostic and therapeutic devices aimed at treating pain and addressing opioid use disorder (OUD). This grant seeks to support the creation of non-addictive device-based technologies, advancing them from early development to preclinical stages suitable for FDA approval, with a focus on demonstrating treatment efficacy through credible neural targets. Eligible applicants include a diverse range of organizations such as higher education institutions, non-profits, for-profit entities, and tribal governments, with funding available for up to three years and a maximum budget of $750,000 annually. Interested parties should note that the application deadline is June 17, 2025, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management," aimed at addressing the national opioid public health crisis. This initiative encourages small businesses to develop innovative, non-addictive therapies and technologies for improved pain management, including new medications, pain-assessment devices, and treatment strategies for chronic pain. The funding available includes up to $275,766 for Phase I and $1,838,436 for Phase II grants, with applications due by April 4, 2025. Interested applicants can find more information and guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative aimed at developing innovative therapies and technologies for enhanced pain management. This initiative specifically seeks applications from small businesses focused on creating non-addictive pain treatment alternatives, objective pain measurement tools, and new screening methodologies to address the national opioid crisis. With an annual funding projection of up to $8 million for 5-15 awards, eligible applicants must be U.S. small businesses, and the application deadline is set for April 4, 2025. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-006.html.
    HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity through the HEAL Initiative aimed at supporting research for non-opioid analgesics via the R61/R33 Exploratory/Developmental Phased Award. This initiative encourages applications that focus on the early translational steps in developing novel pain treatment strategies, including the development and validation of assays and the identification of potential therapeutic agents, while explicitly prohibiting clinical trials. The funding amount is up to $350,000 per year, with a total project period not exceeding three years, and applications are due by January 15, 2027. Interested applicants can find more information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    HEAL Initiative: Discovery and Validation of Novel Targets for Safe and Effective Pain Treatment (R01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative aimed at discovering and validating novel therapeutic targets for safe and effective pain treatment through the R01 Clinical Trial Not Allowed grant. This initiative seeks proposals that focus on basic science research targeting the peripheral nervous system, central nervous system, and other tissues, with an emphasis on developing pain therapeutics that minimize side effects and addiction risks. The NIH plans to award 8-10 grants, with project durations of up to five years, addressing various pain conditions including acute and chronic pain syndromes, amidst the ongoing opioid crisis. Interested applicants must submit their proposals by December 6, 2024, and can find additional information and submission guidelines at the provided NIH link or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov.
    NIH HEAL Initiative: Coordinated Approaches to Pain Care in Health Care Systems (UG3/UH3 - Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative for the implementation of coordinated pain care models within healthcare systems that currently lack such frameworks. This initiative encourages applications for UG3/UH3 phased cooperative agreements that utilize implementation science to enhance multidisciplinary chronic pain management, particularly focusing on populations with significant health disparities. The program aims to foster structured collaborations among healthcare providers, patients, and policymakers to improve access to comprehensive care, with an expected budget of approximately $4 million to fund 3 to 5 projects. Interested applicants must submit their proposals by November 8, 2024, and can find additional information and submission guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative to support the development of non-addictive analgesic therapeutics, specifically small molecules and biologics, aimed at treating pain. The initiative seeks to accelerate the optimization and transition of promising therapeutic candidates to Phase I clinical trials, requiring applicants to demonstrate a compelling biological rationale and suitable assays for their projects. This funding is crucial for addressing the needs of over 25 million Americans suffering from chronic pain while providing alternatives to opioids. Approximately $11 million is anticipated for distribution across four awards in FY 2024, with applications due by January 24, 2024. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov.
    HEAL Initiative-Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is inviting applications for the HEAL Initiative's funding opportunity titled "Early-Stage Discovery of New Pain Targets Within the Understudied Druggable Proteome (R03 Clinical Trial Not Allowed)." This initiative aims to support pilot projects that identify new druggable targets for pain by generating preliminary data on understudied proteins associated with pain management. The funding opportunity is particularly significant as it seeks to advance research in pain management and drug discovery, contributing to the broader goal of addressing the opioid addiction crisis. Eligible applicants can receive up to $100,000 for projects lasting one year, with applications due by July 16, 2026. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-24-197.html.
    HEAL INITIATIVE: Development and validation of remote or patient wearable device derived objective biosignatures or functional assessments to monitor pain for use as endpoints in clinical trials (UG3/UH3 - Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative to develop and validate remote or wearable device-derived biosignatures for monitoring pain, aimed at enhancing clinical trial endpoints. This initiative seeks innovative measurements to assess pain experiences and responses to interventions, emphasizing interdisciplinary collaboration across medical, technological, and patient advocacy fields. The NIH plans to allocate a total budget of $5.1 million to support 4-6 awards, with applications due by October 5, 2024. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-023.html.
    HEAL Initiative: Understanding Individual Differences in Human Pain Conditions (R01 - Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity under the HEAL Initiative aimed at understanding individual differences in human pain conditions through the R01 grant mechanism. This initiative seeks research proposals that focus on the holistic understanding of pain variability among individuals, emphasizing the collection of clinical and preclinical data to inform personalized pain management strategies. The program is particularly relevant in the context of addressing the ongoing opioid crisis and aims to foster innovative, evidence-based solutions for pain treatment by encouraging multidisciplinary approaches and patient engagement. Approximately $4 million is available to support 3-4 awards, with applications due by February 6, 2025. Interested applicants can find more information and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.