Broad Spectrum Products Against Multiple Neurotoxin Botulinum Serotypes (R61/R33 Clinical Trial Not Allowed)
ID: 357668Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357668

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-080.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity aimed at developing broad-spectrum products to counteract Botulinum Neurotoxin (BoNT) intoxication. The initiative seeks to support the creation of therapies that can effectively reverse the effects of BoNT, addressing the limitations of current treatments, which primarily rely on passive immunoglobulin therapy. This funding opportunity utilizes a milestone-driven, biphasic R61/R33 award mechanism, with up to $2.9 million available for 5-6 awards in the R61 phase, focusing on feasibility studies before transitioning to further development in the R33 phase. Interested applicants, including various educational and community organizations, must adhere to NIH's review criteria and submit proposals by May 2, 2025. For more information, applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/rfa-files/RFA-AI-24-080.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-AI-24-080.html
    The National Institutes of Health (NIH), through the National Institute of Allergy and Infectious Diseases (NIAID), announces a funding opportunity for developing products against Botulinum Neurotoxin (BoNT) intoxication. The aim is to advance therapies that can reverse the effects of BoNT, as current treatments are limited to passive immunoglobulin therapy. The initiative encourages milestone-driven research leading to therapeutics for targeted BoNT serotypes, supporting both basic and preclinical development. The R61/R33 Exploratory/Developmental Phased Award allows applicants to propose a dual-phase project: an initial R61 phase for feasibility studies, followed by an R33 phase focused on further development. Up to $2.9 million is allocated for 5-6 awards for the R61 phase. Eligible applicants include various institutions and organizations, and applicants are required to adhere to NIH’s rigorous review criteria, including significance, innovation, approach, and investigator qualifications. Importantly, clinical trial applications are not permitted under this grant opportunity. This funding aims to fill critical gaps in effective therapies against BoNT, highlighting advancements in biomedical research on infectious diseases.
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