Development of Biomarkers or Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)
ID: 338276Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/338276

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-22-089.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity titled "Development of Biomarkers or Biomarker Signatures for Neurological and Neuromuscular Disorders (R61/R33 Clinical Trial Optional)." This initiative aims to support the discovery and early evaluation of candidate biomarkers that can facilitate the clinical development of neurotherapeutics and their application in clinical practice, with a focus on both animal studies and preliminary human evaluations. The program emphasizes the importance of collaboration among multidisciplinary researchers and aims to enhance therapeutic development efficiency for neurological conditions, ultimately propelling candidate biomarkers towards widespread clinical use. Interested applicants must submit their proposals by May 7, 2025, and can find additional information and application details at http://grants.nih.gov/grants/guide/pa-files/PAR-22-089.html. For inquiries, contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov.

    Point(s) of Contact
    OERWebmaster03@od.nih.gov
    Files
    Title
    Posted
    PAR-22-089-Full-Announcement.html
    PAR-22-089.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity focused on the development of biomarkers for neurological and neuromuscular disorders. This initiative, known as the R61/R33 clinical trial optional phased award, encourages studies that begin with proof-of-concept biomarker discovery followed by preliminary clinical validation. Applicants must demonstrate that their candidate biomarkers effectively correlate with the clinical concepts of interest and address significant unmet needs in clinical practice. Key objectives include optimizing detection methods and establishing the biomarker's clinical utility for defined contexts of use. The support encompasses multidisciplinary expertise, emphasizing the importance of collaboration among researchers skilled in biomarker development, clinical practice, and statistical analysis. The project duration spans up to five years, with applications evaluated based on their significance, innovation, and rigor. This funding mechanism aims to enhance therapeutic development efficiency for the nervous system, providing crucial tools for clinical decision-making, and emphasizes the importance of employing rigorous biological, analytical, and clinical validation methods. The overall goal is to propel candidate biomarkers towards widespread clinical application, with an emphasis on neurotherapeutics.
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