NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)
ID: 352165Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $350K

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/352165

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-24-124.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity through the NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33), aimed at supporting investigator-initiated clinical trials focused on natural products such as botanicals and dietary supplements. This initiative seeks to encourage research that demonstrates a strong scientific premise for further testing, with the R61 phase providing up to three years of funding for milestone-driven studies assessing pharmacokinetics, bioavailability, and the effects of these products on specific target mechanisms. Successful projects may receive an additional three years of funding in the R33 phase to evaluate clinical outcomes related to target engagement. Interested applicants can submit proposals starting February 4, 2024, with a maximum project duration of five years, and should include a Plan for Enhancing Diverse Perspectives (PEDP) as part of their application. For further inquiries, applicants can contact NIH Grants Information at grantsinfo@nih.gov, and the award ceiling is set at $350,000.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-24-124-Full-Announcement.html
    PAR-24-124.html
    The National Center for Complementary and Integrative Health (NCCIH) of the Department of Health and Human Services has issued a Notice of Funding Opportunity (NOFO) for the NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33). This initiative supports investigator-initiated clinical trials focusing on natural products—such as botanicals and dietary supplements—with strong scientific backing for further testing. The R61 phase provides up to three years of funding to assess pharmacokinetics, bioavailability, and the product's effects on target mechanisms through milestone-driven studies. If successful, the R33 phase may receive additional funding for up to three more years to further evaluate clinical outcomes related to target engagement. The application process requires adherence to specific guidelines, including submitting a Plan for Enhancing Diverse Perspectives (PEDP), and proposals that do not include this plan will be considered incomplete. Overall, this funding opportunity aims to foster early-stage clinical testing of natural products, accelerating the translation of scientific findings into practical applications, while prioritizing inclusiveness and adherence to regulatory standards. Applications can be submitted beginning February 4, 2024, with a maximum project duration of five years.
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