The Department of Health and Human Services, through the National Center for Complementary and Integrative Health (NCCIH), has issued a Notice of Funding Opportunity (NOFO) titled "NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)." This funding aims to support mid-phase clinical trials on natural products, including botanicals, dietary supplements, and probiotics, which show promising preliminary evidence for health benefits. The objective is to gather robust data on the optimal dosing and target engagement of these products before advancing to larger efficacy trials. Key requirements for applicants include providing sufficient preliminary data, adherence to FDA regulations, and developing a Plan for Enhancing Diverse Perspectives (PEDP) to encourage inclusivity in research. Applications must propose randomized controlled trials with strong scientific justification and are limited to specific types of studies. Funding decisions will prioritize research that addresses knowledge gaps in complementary health approaches, particularly in symptom management and health disparities. The application process includes detailed guidelines, registration requirements, and a streamlined submission through Grants.gov. The deadline for applications is set for 5:00 PM local time of the applicant organization, with ongoing reviews and programmatic priorities outlined by NCCIH.