The Department of Health and Human Services, through the National Institutes of Health (NIH), is issuing a Notice of Funding Opportunity (NOFO) for the Natural Product Multi-Site Clinical Trial Data Coordinating Center (DCC). This initiative supports collaborative applications for a DCC that partners with a Clinical Coordinating Center (CCC) to execute multi-site efficacy or effectiveness trials of natural products. Both applications must be submitted simultaneously, with a comprehensive plan detailing project coordination, data management, and biostatistical support required. Key components include maintaining the integrity of data collection, ensuring diversity in participant recruitment, and completing specific milestones to obtain continued funding. The application encourages inclusivity and requires a Plan for Enhancing Diverse Perspectives (PEDP) to promote diverse viewpoints in research. Budget requests must reflect actual project needs, with cooperative agreements expected to last up to five years, expandable to seven if justified. Eligibility includes a range of organizations, prioritizing those serving underrepresented communities. The NOFO emphasizes scientific merit through rigorous review processes and requires adherence to detailed application and submission instructions. This funding opportunity ultimately aims to deepen the understanding of natural products' effects on health in multi-site clinical trial settings while ensuring stakeholder engagement in the research process.