The National Institutes of Health (NIH) is inviting cooperative agreement applications for the establishment of a Clinical Coordinating Center (CCC) as part of multi-site, investigator-initiated clinical trials aimed at evaluating natural products, including botanicals and dietary supplements. This funding opportunity, designated as PAR-24-123, emphasizes rigorous investigation into the efficacy of natural products, requiring applicants to present comprehensive scientific and operational plans. A two-phase cooperative agreement funding mechanism, UG3/UH3, will be employed to facilitate trial setup and implementation. The CCC's responsibilities include managing project logistics, participant recruitment, and maintaining scientific integrity, while an accompanying Data Coordinating Center (DCC) is mandated to ensure independent data management and analysis. The NOFO emphasizes the necessity for a Plan for Enhancing Diverse Perspectives (PEDP), which will be a key component of the application evaluation. Additionally, applicants must demonstrate substantial preliminary data validating the proposed natural products, including evidence of safety and bioavailability. The NIH encourages early interaction with its scientific staff to refine proposals and align them with their strategic research priorities. This funding initiative highlights the NIH's dedication to exploring complementary health strategies through scientifically rigorous approaches.