The National Institutes of Health's National Center for Complementary and Integrative Health (NCCIH) invites applications for mid-phase clinical trials focusing on natural products such as botanicals and dietary supplements through the NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required) funding opportunity (PAR-24-115). This initiative seeks to support trials that evaluate optimal doses, formulations, and patient responses, backed by preliminary data demonstrating bioavailability and measurable target engagement. The proposal should exclude single-site efficacy trials and those aimed at cancer treatment. Key application components include a Plan for Enhancing Diverse Perspectives (PEDP), which must be included in submissions, and focus on priority areas such as symptom management and minority health. Funded projects can request budgets up to $350,000 annually, with a maximum project period of five years. The submission process emphasizes the importance of compliance with NIH registration and guidelines, and a well-defined timeline is essential for milestone completion. Applications will undergo a peer review process to assess significance, investigator qualifications, innovation, and the study's approach. The deadline for submission is set for March 2026, with a strong emphasis on ensuring diverse perspectives in research.