Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) (U01 Clinical Trial Optional)
ID: 355145Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $3M

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/355145

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-25-195.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a funding opportunity titled "Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH)," aimed at promoting innovative research in mental health through the development of individualized clinical signatures. This initiative encourages applicants to propose novel behavioral tasks and utilize existing datasets to enhance clinical decision-making and patient outcomes in mental disorders, emphasizing the need for diverse research teams and a Plan for Enhancing Diverse Perspectives (PEDP). Up to $15 million is available to support up to six awards, with each project eligible for a maximum budget of $2.5 million over a five-year period. Interested applicants should refer to the full announcement for guidelines and submit their proposals by October 18, 2024, while adhering to FAIR data principles for data sharing. For further inquiries, contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-MH-25-195-Full-Announcement.html
    RFA-MH-25-195.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH) and the National Institute of Mental Health (NIMH), has announced a funding opportunity titled "Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH)." This initiative aims to promote research that leverages behavioral assessments and computational methods to create individualized clinical signatures for predicting outcomes and guiding clinical decision-making in mental disorders. Applicants are encouraged to propose innovative behavioral tasks, utilize existing datasets, and derive new clinical signatures from integrated behavioral and clinical record data. The funding opportunity emphasizes the importance of diverse research teams and requires a Plan for Enhancing Diverse Perspectives (PEDP). Up to $15 million will be allocated, supporting up to six awards with a maximum budget of $2.5 million each for a project period of five years. The application process necessitates adherence to specific guidelines, including compliance with FAIR data principles for data sharing. Overall, this program seeks to foster individualized approaches in mental health research and clinical practice, moving beyond traditional diagnostic methods to enhance patient care.
    Similar Opportunities
    Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations II (U24 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), has announced a Notice of Funding Opportunity (NOFO) titled "Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations II" (PAR-24-241), aimed at establishing a Coordinating Center to enhance psychiatric genetic studies in diverse populations. This initiative seeks to address the underrepresentation of genetic data from non-European ancestries in mental health research, promoting data harmonization, joint analyses, and ethical practices while fostering collaboration among various research projects. Eligible applicants include higher education institutions, non-profits, tribal governments, and other organizations, with the application period opening on September 11, 2024, and a maximum award period of five years. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov, and additional details can be found at the provided link: https://grants.nih.gov/grants/guide/pa-files/PAR-24-241.html.
    Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression (UG3/UH3 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Precision Mental Health: Develop Tools to Inform Treatment Selection in Depression" through a cooperative agreement mechanism. This initiative aims to accelerate the development and validation of predictive tools and biomarkers that can guide treatment selection for depression, structured in two phases: the UG3 phase focuses on identifying candidate tools through data analysis or pilot studies, while the UH3 phase involves conducting clinical trials for validation. The total funding available for FY 2025 is $5 million, with up to $500,000 per year for UG3 projects and $1.5 million per year for UH3 projects. Eligible applicants include a diverse range of institutions and organizations, and proposals must address unmet clinical needs and include comprehensive data management plans. Interested parties can find more information and contact NIH Grants Information at grantsinfo@nih.gov, with proposals due by October 18, 2024.
    Clinical Studies of Mental Illness (Collaborative R01) (Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Clinical Studies of Mental Illness (Collaborative R01)" aimed at supporting multidisciplinary clinical studies focused on mental health, particularly in areas such as genetics, biomarkers, and various mental illnesses. This initiative encourages collaboration across multiple sites to enhance sample sizes and diversity in participant recruitment, specifically targeting health disparity populations. The program allows for a project period of up to five years with no explicit budget limits, although proposed budgets must be well justified. Interested applicants, including various educational and nonprofit institutions, should submit their applications by January 7, 2026, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries. For more details, applicants can refer to the full announcement available at https://grants.nih.gov/grants/guide/pa-files/PAR-23-050.html.
    Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations II (U01 Clinical Trial Not Allowed)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations II (U01 Clinical Trial Not Allowed)" aimed at enhancing the understanding of psychiatric disorders in diverse populations, particularly those of African ancestry. This initiative seeks applications for cooperative agreements that will focus on accelerating gene discovery efforts and promoting global mental health equity, addressing the existing gap in genomic studies that predominantly center on European populations. The funding is intended to support innovative research approaches that incorporate community engagement and career development for underrepresented groups, with a project period of up to five years. Interested applicants can find more details and submit inquiries via the NIH Grants Information email at grantsinfo@nih.gov, with the application deadline set for February 13, 2026.
    Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is offering a funding opportunity titled "Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)." This initiative invites interdisciplinary teams to apply for grants aimed at advancing the understanding of mental disorders through innovative neuroscience research, focusing on the underlying mechanisms of mental illnesses, the integration of basic and clinical neuroscience, and the neurobehavioral development of psychopathology. The program is designed to support collaborative projects that address complex scientific questions that cannot be pursued through standard research mechanisms, with funding available for up to five years and direct costs capped at $2 million annually. Interested applicants can find more information and application guidelines at the provided link, and they must submit their proposals by June 9, 2025.
    Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders" (FOA Number PAR-23-093). This grant aims to promote research focused on invasive neural recording studies that explore the neural circuitry underlying mental health disorders, with an emphasis on high translational potential in understanding moods, cognitive functions, and behaviors. The initiative encourages collaboration among diverse research teams in fields such as neurosurgery, electrophysiology, and psychology, while specifically excluding general neuroscience studies that do not focus on mental health or intervention development. Interested applicants can submit proposals until January 7, 2025, with no specific budget limits for projects that may extend up to five years; for further inquiries, contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-23-093.html.
    Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity for the Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (R61/R33 Clinical Trial Required). This initiative aims to support innovative clinical trials that investigate novel interventions for mental health conditions, including schizophrenia, depression, and anxiety, with a focus on establishing proof of mechanism and target engagement in the R61 phase and confirming findings on a larger scale in the R33 phase. The total funding commitment for this initiative is $27 million for FY 2022, and eligible applicants include a diverse range of entities such as higher education institutions, nonprofits, and various government organizations, both domestic and foreign. Interested parties should note that the application deadline is October 15, 2024, and can reach out to the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for further inquiries.
    Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is inviting applications for the Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01 Clinical Trial Required) grant. This funding opportunity aims to support clinical trials that assess the efficacy of non-pharmacological interventions for mental disorders in both adults and children, focusing on addressing unmet therapeutic needs and enhancing understanding of the mechanisms of action through rigorous experimental therapeutics approaches. The NIMH plans to commit approximately $27 million to fund various companion funding opportunities, with applications due by October 15, 2024. Interested applicants can find additional information and application procedures at the provided NIH link or contact the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV for assistance.
    Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), is offering a funding opportunity for the Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required). This initiative aims to support pilot research focused on innovative psychosocial intervention strategies for both adults and children, emphasizing the experimental therapeutic approach to address underlying mechanisms of mental disorders. The funding will facilitate exploratory clinical trials for up to three years, with no specific budget limits, provided they reflect actual project needs, and applications must demonstrate a strong scientific rationale and empirical support. Interested applicants can find more information and application details at the provided NIH link, with a submission deadline of October 15, 2024.
    Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)
    Active
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a grant opportunity titled "Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)." This funding initiative aims to support invasive neural recording studies that address mental health-related questions, focusing on understanding the neural circuitry and dynamics underlying complex behaviors, emotions, and cognitive functions. The R21 grant mechanism encourages innovative, short-term research proposals with a budget of up to $275,000 over two years, while emphasizing the importance of diverse research teams from various clinical fields. Interested applicants should note that the application deadline is January 7, 2025, and can find further details and guidelines at the NIH grants website or by contacting NIH Grants Information at grantsinfo@nih.gov.