The National Institutes of Health (NIH) is inviting applications for the Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research, a federal grant opportunity aimed at advancing research in mental health. This initiative seeks interdisciplinary teams to explore high-impact questions related to the mechanisms of mental disorders, integrating basic and clinical neuroscience research, and understanding the developmental trajectories of psychopathology from childhood through adolescence. The program emphasizes innovative and collaborative approaches that cannot be supported through standard grant mechanisms, with funding available for direct costs up to $2 million annually for projects lasting a maximum of five years. Applications are due by June 9, 2025, and interested parties can find more information and submission guidelines at the NIH grants website or contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov.