The National Institutes of Health (NIH), through the National Institute of Mental Health (NIMH), has issued a funding opportunity titled "Genetic Architecture of Mental Disorders in Ancestrally Diverse Populations." This initiative aims to enhance understanding of psychiatric disorders by accelerating gene discovery within non-European ancestry cohorts. The funding seeks cooperative agreements to fall under the U01 activity code, and proposes projects that utilize modern genomic techniques alongside clinical assessments. The program emphasizes the importance of inclusive research, advocating for diversity in population studies to identify risk variants relevant across varying ancestries. Applications must incorporate career development and community engagement components, fostering a collaborative research culture while addressing health equity in global mental health. Key dates include application submission opening on September 11, 2024, with an expiration date of February 14, 2026. Projects should plan for rigorous data sharing and adherence to NIH policies, and the awarded grants will support initiatives for up to five years. Principally, this funding opportunity underscores the NIH’s commitment to correcting historical biases in mental health research, thereby enriching scientific understanding across diverse populations.