The Department of Health and Human Services presents a Limited Competition Basic Instrumentation Grant (BIG) Program funded by the National Institutes of Health (NIH). This program aims to provide financial support for eligible institutions that wish to purchase specialized scientific instruments essential for advancing NIH-funded research. Institutions must not have received substantial S10 funding (over $500,000) in the past three fiscal years and must demonstrate significant need from a group of Major Users, typically requiring at least three NIH-funded researchers to advocate for the instrument. Grants range from a minimum of $25,000 to a maximum of $350,000, with applications due by June 1 of the submission years 2025, 2026, and 2027. Key components of the application process include demonstrating technical expertise, an organizational management plan, and adequate institutional commitment for ongoing support and maintenance of the instrument. Additionally, the program emphasizes collaboration and shared usage among various research groups, enhancing access to modern technologies across a broad research community. Ultimately, the BIG Program endeavors to invigorate institutional research capabilities in the biomedical field through the provision of cutting-edge instrumentation.