The National Institutes of Health (NIH), specifically the National Institute of Biomedical Imaging and Bioengineering (NIBIB), has announced a funding opportunity within the National Centers for Biomedical Imaging and Bioengineering (NCBIB) to promote research and development of innovative technologies in biomedical research. The funding, under the P41 grant mechanism, allows applications for new, renewal, or resubmission projects, with a maximum support period of five years, limited to a total of 15 years. The NCBIB aims to enhance collaboration among researchers by providing essential technologies and training while fostering a nationwide impact through technology dissemination. The primary focus is on Technology Research and Development (TR&D) projects, which should address emerging biomedical needs and establish a synergistic relationship with Collaborative Projects (CPs) and Service Projects (SPs). Applicants are encouraged to submit Letters of Intent eight weeks prior to deadlines and to adhere strictly to the application requirements outlined in the guidance documents. This grant opportunity supports early-stage clinical trials but does not fund advanced phase trials. Overall, this funding initiative is integral to advancing biomedical technologies through collaborative and translational efforts in the research community.