The Department of Health and Human Services, through the National Institutes of Health (NIH), announces the Shared Instrumentation Grant (SIG) Program (PAR-24-265) aimed at encouraging collaborative applications from NIH-supported investigators to acquire specialized, high-cost instruments for research purposes. The program targets instruments valued between $50,000 and $750,000 for shared use in basic, translational, or clinical biomedical research. Eligible applicants include higher education institutions, non-profits, and government entities, with specific encouragement for historically underrepresented institutions. The application periods open on May 2, 2025, with a project period of one year. Key requirements include demonstrating a community of significant users, an Advisory Committee for oversight, and detailed financial and operational plans. Notably, applications are strictly non-clinical, and funding is limited to purchase costs without indirect costs or support for technical personnel. Applications must follow rigorous compliance guidelines and include well-justified needs for the requested instruments, technical expertise from users, and a commitment to broad access and shared usage. Monitoring and reporting requirements post-award include annual usage reports and a final performance report detailing the impact of the funded instrument on research endeavors.