The Department of Health and Human Services, through the National Institutes of Health (NIH), has reissued the High-End Instrumentation (HEI) Grant Program (Funding Opportunity PAR-24-264) to support the purchase or upgrade of specialized high-end biomedical research instruments. The program aims to facilitate shared access to advanced technologies essential for NIH-funded projects, with funding ranging from a minimum of $750,001 to a maximum of $2,000,000 per application. Key instruments eligible include mass spectrometers, electron microscopes, and MRI systems. Eligible applicants include a variety of educational institutions and nonprofit organizations, with an emphasis on encouraging participation from diverse institutions. The program mandates that instruments can only be used for biomedical research and requires detailed justifications for the requested technology. Applications are due by May 2, 2025, and specific guidelines must be followed to ensure compliance, including submission through Grants.gov and adherence to page limits for various sections of the application. The review process will assess the scientific merit, administrative capability, and institutional commitment, ultimately aiming to promote cost-effective sharing and utilization of high-end research instruments among investigators.