The National Institutes of Health (NIH) is offering a funding opportunity titled "Addressing the Impact of Syndemics on the Health of People with HIV and Diseases and Conditions within the Missions of NIDDK and NHLBI (R01 Clinical Trial Optional)." This initiative aims to support research projects that investigate the synergistic effects of co-occurring health conditions, particularly among marginalized individuals living with HIV, while addressing factors such as racism, marginalization, and stigma. Proposals must adhere to a syndemics framework and include a Plan for Enhancing Diverse Perspectives (PEDP), with a maximum project period of five years and a budget cap of $500,000 per year. The funding opportunity opens for submissions on February 20, 2024, with a total of $3.3 million allocated for NIDDK and $1.54 million for NHLBI to support multiple awards each fiscal year. Interested applicants can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries and should refer to the full announcement at https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-25-001.html.