Using Neuromodulation to Characterize the Continuum of Pathophysiology Between Substance Use and Mental Health Disorders (R01 Clinical Trial Required)

Active
Yes
Status
Posted
Published Date
April 15th, 2024
Close Date
August 15th, 2024
Opportunity No.
RFA-DA-25-035

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) has posted a grant opportunity titled "Using Neuromodulation to Characterize the Continuum of Pathophysiology Between Substance Use and Mental Health Disorders (R01 Clinical Trial Required)". This grant aims to support research efforts in the field of Substance Use Disorder (SUD) and Mental Health Disorders (MHD) by investigating the effects of neuromodulation on brain circuits and behaviors related to both SUD and MHD. The research studies funded by this grant will focus on identifying inclusion/exclusion criteria that capture the variability in symptoms of both SUD and MHD. Additionally, the studies will involve measuring the engagement of circuit-level targets in response to neuromodulation and assessing cognitive and behavioral dimensions relevant to both SUD and MHD. The ultimate goal is to gain a better understanding of neurobehavioral function and develop accurate models of dysfunction shared and distinct between these conditions. This grant opportunity falls under the category of Health and is classified as a discretionary grant. The grant does not require cost sharing or matching. The closing date for applications is August 15, 2024, and the archive date is September 20, 2024. Eligible applicants include various institutions and organizations, such as Alaska Native and Native Hawaiian Serving Institutions, Faith-based or Community-based Organizations, and U.S. Territories or Possessions. For more information and to apply, please visit the following link: Additional Information. If you have any inquiries, you can contact NIH Grants Information at grantsinfo@nih.gov.

Description

This NOFO seeks applications from the SUD and MHD research communities that coordinate efforts to characterize the effects of neuromodulation on brain circuits and behaviors relevant to both SUD and MHD. To accomplish this goal, studies would specify inclusion/exclusion criteria to capture variance in both SUD and MHD symptoms. Further, studies would include measures of engagement of circuit-level targets in response to neuromodulation and dimensional measures of cognition and behavior relevant to both SUD and MHD. This research approach uses circuit dynamics to understand neurobehavioral function and to develop ecologically valid and descriptive models of the shared and discrete dysfunction across these conditions.

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