The National Institutes of Health (NIH) is offering a funding opportunity for research projects aimed at using neuromodulation to explore the continuum of pathophysiology between substance use disorders (SUD) and mental health disorders (MHD). The initiative seeks applications that investigate the effects of neuromodulation on brain circuits and behaviors relevant to both SUD and MHD, requiring studies to include diverse participant criteria and measures of engagement with circuit-level targets. With an estimated funding commitment of $2 million for fiscal year 2025, the NIH plans to award up to four grants, with a maximum project duration of five years. Interested applicants must adhere to strict submission guidelines, with a critical deadline for applications set for July 15, 2024, and can direct inquiries to grantsinfo@nih.gov.