Cooperative AgreementPostedDiscretionary

Device Based Treatments for Substance Use Disorders (UG3/UH3 Clinical Trial Optional)

National Institutes of Health
PAR-25-023
Application Deadline
Aug 13, 2026
152 days left
Days Remaining
152
Until deadline
Award Ceiling
$500,000
Total Program Funding

Grant Opportunity Analysis

The National Institutes of Health (NIH) is offering a funding opportunity titled "Device Based Treatments for Substance Use Disorders (UG3/UH3 Clinical Trial Optional)" aimed at accelerating the development of device-based treatments for Substance Use Disorders (SUDs). This initiative seeks to support both pre-clinical and clinical development phases through a cooperative agreement format, which includes an initial UG3 phase of up to two years, followed by a potential UH3 phase lasting three additional years, contingent upon successful milestone achievement. The program emphasizes innovative approaches to understanding device mechanisms and treatment outcomes, particularly for SUDs lacking effective current treatments, and requires proposals to include quantifiable milestones and collaboration with NIH staff. Interested applicants can find more information and submission guidelines at the provided link, with an award ceiling of $500,000 and a closing date for applications set for August 13, 2026. For inquiries, applicants may contact NIH Grants Information at grantsinfo@nih.gov.

Eligible Applicants

Others
Additional Eligibility Information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grant Documents

1 Files
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AI Summary
The Department of Health and Human Services, through the National Institutes of Health (NIH), is issuing a funding opportunity (PAR-25-023) aimed at accelerating the development of device-based treatments for Substance Use Disorders (SUDs), including neuromodulatory devices. This initiative seeks to support pre-clinical and clinical development phases through a UG3/UH3 cooperative agreement format, which comprises two phases: the initial UG3 phase lasting up to two years, followed by a potential UH3 phase for three additional years, contingent upon successful milestone achievement. The funding focuses on understanding device mechanisms and potential treatment outcomes for various SUDs, especially for conditions lacking current effective treatments. Proposals must include quantifiable milestones, adhere to regulatory requirements, and emphasize collaboration with NIH staff throughout the process. Additionally, submission guidelines highlight the importance of registration in various electronic systems and adherence to specific criteria for application review. The program encourages innovative approaches, the evaluation of device efficacy, and exploration of the relationship between device use and behavioral changes in patients suffering from SUDs.

Related Grant Opportunities

Project Timeline

postedOriginal Opportunity PostedJul 12, 2024
deadlineApplication DeadlineAug 13, 2026
expiryArchive DateSep 18, 2026

Funding Details

Award Ceiling
$500,000
No cost sharing required

Agency & Classification

Agency
National Institutes of Health(HHS-NIH11)
Funding Category
Health
Funding Instrument
Cooperative Agreement

Grantor Contact

CFDA Numbers

93.279

Official Sources