The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for a limited competition grant titled "NIMHD Initiative for Improving American Indian and Alaska Native Cancer Outcomes (U01- Clinical Trial Optional)". This initiative aims to support research on improving cancer outcomes in American Indian and Alaska Native populations. The funding opportunity will be open to National Cancer Institute (NCI)-designated Cancer Centers with existing community outreach and collaborations with these populations. The expected publication date for the funding opportunity is Summer 2024, with an application due date in Summer 2024. The funding will be provided through cooperative agreements, and there is no cost sharing or matching requirement. The estimated total program funding is $6,000,000. Private Institutions of Higher Education are eligible to apply. The anticipated award date is September 2024, and the project is expected to start on September 30, 2024.