The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the NCI National Clinical Trials Network (NCTN) - Network Group Operations Centers, which will require a U10 clinical trial. This initiative aims to provide scientific leadership for the development and implementation of multi-disciplinary, multi-institutional clinical trials targeting various cancer types and populations, focusing on late-phase treatment trials and advanced imaging studies. The NCTN plays a crucial role in conducting comprehensive clinical research for patients of all ages with cancer, including preliminary studies for definitive trials. The estimated total program funding is $99,300,000, with the NOFO expected to be published in Fall 2024 and applications due by late February 2025. For further details, interested applicants should prepare their proposals in advance of the anticipated timeline.