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The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a funding opportunity aimed at expanding cancer screening and preventive services among populations that face health disparities. This initiative, designated as the R01 Research Project Grant (NOFO Number PAR-23-170), seeks applications focused on testing interventions that address barriers to cancer screening and prevention. Eligible applicants include a wide range of organizations such as universities, nonprofits, and government entities. The funding aims to develop multi-level interventions addressing patient, clinician, healthcare setting, and community barriers to improve health outcomes. Collaborations with community partners and service providers are encouraged to enhance the efficacy of interventions. Projects may last up to five years and must adhere to rigorous application instructions. Key deadlines for application submissions span from October 5, 2023, to January 8, 2027. The review process includes assessing the significance, innovation, approach, and investigator qualifications of the proposals submitted. This funding opportunity aligns with the NIH's commitment to promote health equity by advancing prevention research in historically underserved populations, thereby reducing cancer-related disparities across the U.S.