The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the NCI National Clinical Trials Network (NCTN) - Network Lead Academic Participating Sites, aimed at enhancing clinical trial capabilities in cancer research. This initiative seeks small businesses to provide scientific leadership and support in developing and conducting multi-center, late-phase clinical treatment trials, particularly focusing on diverse patient populations and various cancer modalities. The funding opportunity is critical for advancing the NCI's clinical research program, with an estimated total program funding of $35.1 million and an award ceiling of $1.7 million for approximately 35 expected awards. Interested applicants should prepare for the application process, as the NOFO is anticipated to be published in Fall 2024, with applications due in late February 2025.