The National Institutes of Health (NIH) plans to publish a funding opportunity announcement for a single-source grant aimed at establishing the NCI National Clinical Trials Network - Canadian Collaborating Clinical Trials Network. This initiative seeks to partner with private institutions of higher education to conduct large-scale, multi-site clinical trials, focusing on late-phase treatment trials and advanced imaging across various cancer types, while ensuring regulatory oversight in Canada. The funding, estimated at $3.8 million, is intended to support the NCTN's efforts to enhance clinical research for diverse patient populations, with the application due in late February 2025 and the award date anticipated for March 1, 2026. Interested applicants should prepare their proposals in advance of the expected announcement in Fall 2024.

The National Cancer Institute (NCI) intends to issue a U10 NCI National Clinical Trials Network (NCTN) &#65533; Canadian Collaborating Clinical Trials Network notice of funding opportunity (NOFO). The NCTN Canadian Collaborating Clinical Trials Network will be a full partner with the U.S. Network in the conduct of large-scale, multi-site clinical trials and help provide regulatory expertise/oversight for the conduct of NCTN trials in Canada. This. The primary goal of the NCTN is the conduct of multi-center, late-phase, clinical treatment trials (i.e., randomized phase 2 and phase 3 trials) and advanced imaging trials across a broad range of cancers, modalities, and diverse patient populations with relevance to the U.S. patient population as part of the NCI&apos;s overall clinical research program for adults, adolescents and young adults, and children with cancer. The NCTN also conducts umbrella/basket trials and rare tumor trials, when an extensive, national patient catchment area is required. This Notice of Intent to Publish is being provided to allow sufficient time for the applicant to develop a strong application. The NOFO is expected to be published in Fall 2024 with only one expected application due date in late February 2025. &#65533;

Notice of Intent to Publish a Funding Opportunity Announcement for Single Source: NCI National Clinical Trials Network - Canadian Collaborating Clinical Trials Network (U10 Clinical Trial Required)

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