The National Institutes of Health (NIH) is offering the Small Business Transition Grant for New Entrepreneurs (R43/R44 Clinical Trial Not Allowed) to support early-career scientists transitioning into entrepreneurship. This grant aims to facilitate the career development of investigators by providing entrepreneurial training, mentorship, and the opportunity to conduct research and development within small business concerns (SBCs). The initiative is particularly focused on fostering diversity among applicants and ensuring that Program Directors/Principal Investigators (PDs/PIs) develop the necessary skills to bridge scientific expertise with entrepreneurial capabilities in health-related fields. Interested applicants can find more information and apply by April 5, 2027, with Phase I budgets capped at $306,872. For inquiries, contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-24-131.html.