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The National Institutes of Health (NIH) has issued a Notice of Funding Opportunity (NOFO) for the Small Business Transition Grant for New Entrepreneurs, aimed at facilitating early-career scientists' transition to entrepreneurship. This initiative emphasizes research and development activities while providing mentorship and entrepreneurial training for Program Directors/Principal Investigators (PDs/PIs). Eligible applicants include U.S. small business concerns led by individuals with limited entrepreneurial experience. The grant supports Phase I and Fast-Track applications but excludes those proposing clinical trials. Key components of the program include strong mentorship, a tailored career development plan focusing on entrepreneurial skill enhancement, and a commitment to fostering diversity in the scientific workforce. Application deadlines range from September 2024 to April 2027, with specific budget guidelines for Phase I and Phase II projects. NIH encourages applicants to engage with program officials beforehand to ensure alignment with NIH priorities and to explore available resources for successful applications. This funding opportunity seeks to promote innovation, improve health outcomes, and commercialize scientific advancements.