The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) aimed at understanding the impact of social determinants of health (SDoH) on cancer disparities among people with HIV (PWH). This initiative seeks applications for research that explores health disparities throughout the cancer care continuum, including aspects such as screening, diagnosis, treatment, quality of life, and survivorship, with the goal of enhancing the NIH's research portfolio in this critical area. The funding opportunity, which will utilize the U01 cooperative agreement mechanism, anticipates awarding approximately four grants with a ceiling of $500,000 each, contributing to an estimated total program funding of $3 million. Interested applicants should prepare for the expected publication of the NOFO in fall 2024, with application deadlines projected for winter 2025, 2026, and 2027, and an anticipated award date of July 1, 2025.