The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the Alcohol-HIV/AIDS Program Project, focusing on research related to comorbidities, coinfections, and complications associated with alcohol use and HIV/AIDS. This initiative aims to support innovative research that can lead to effective interventions to reduce HIV transmission and improve health outcomes for individuals living with HIV, particularly in the context of aging and alcohol-related health issues. The funding opportunity will utilize the NIH Program Project (P01) mechanism, with an estimated total program funding of $9 million and an award ceiling of $1 million for up to 8 expected awards. The NOFO is anticipated to be published in Summer 2025, with applications due in Fall 2025, and the estimated project start date is set for August 1, 2026.