The National Institutes of Health (NIH) is planning to publish a Notice of Funding Opportunity (NOFO) for the NINDS Program Project Grant (P01 Clinical Trial Optional). This grant aims to support innovative and interactive research that addresses significant scientific questions related to the mission of the National Institute of Neurological Disorders and Stroke (NINDS). The grant encourages collaboration between outstanding scientists who may not typically work together. The program project grant will fund several interdependent projects that offer scientific advantages over individual research grants. The NOFO is expected to be published in April 2024, with application due dates in May and September 2024. After September 2024, no further applications will be accepted, and the program will end. The grant will utilize the P01 activity code.