The National Institutes of Health (NIH) has announced a funding opportunity titled "Behavioral and Integrative Treatment Development Program (R34 Clinical Trial Optional)" aimed at advancing research in behavioral interventions for substance use and dependence. This initiative encourages the development and testing of innovative behavioral treatments, focusing on enhancing treatment efficacy and community applicability through three stages of research: intervention creation and pilot testing (Stage I), controlled research settings (Stage II), and real-world efficacy assessments (Stage III). The program is particularly significant as it seeks to integrate new scientific findings and technologies to improve outcomes for individuals facing substance use disorders across diverse populations. Eligible applicants, including higher education institutions and non-profits, can apply for funding up to $450,000 over three years, with a submission deadline of March 21, 2025. For further inquiries, interested parties may contact the NIH OER Webmaster at OERWebmaster03@od.nih.gov or visit the additional information link at http://grants.nih.gov/grants/guide/pa-files/PAR-22-183.html.