The National Institutes of Health (NIH) is soliciting research proposals under the grant opportunity titled "Exploring Proteogenomic Approaches to Unravel the Mechanisms of Mis-Folded Protein Accumulation in Tauopathies." This funding initiative encourages innovative research to investigate the accumulation of misprocessed proteins in Tauopathies, focusing on specific brain regions and cell types. Researchers are expected to develop advanced proteogenomic platforms to analyze dynamic protein-misfolding responses relevant to Alzheimer’s Disease and related dementias, aiming to identify novel therapeutic targets. The funding opportunity will provide up to $4 million in FY 2024 to support 4-6 projects, with a budget cap of $500,000 in direct costs per year for a maximum of five years. Applications must be submitted electronically via Grants.gov by June 11, 2024, and must adhere strictly to the format and guidelines provided. Key eligibility includes various institutions, non-profits, and for-profit organizations, with a strong emphasis on collaboration. The review process will evaluate significance, investigator qualifications, innovation, approach, and environment. This initiative represents a critical step in dementia research, aiming to unveil the underlying mechanisms of protein misprocessing and its implications for neurodegenerative diseases.