The National Institutes of Health (NIH) is offering a funding opportunity through the R01 Clinical Trial Optional grant to enhance research on neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) and related dementias. The initiative aims to advance the understanding of the biobehavioral and neurobiological mechanisms underlying NPS, which include symptoms such as aggression, depression, and agitation, thereby addressing significant challenges in patient care. This funding opportunity encourages innovative studies across multiple research levels and is open to a diverse range of applicants, including minority-serving institutions and newer researchers, with a maximum funding period of five years. Interested applicants should note that the next application deadline is October 5, 2023, and can find more information by contacting NIH Grants Information at grantsinfo@nih.gov or visiting the announcement page at https://grants.nih.gov/grants/guide/pa-files/PAR-23-207.html.