The National Institutes of Health (NIH) is offering a funding opportunity for research on current topics in Alzheimer's disease (AD) and its related dementias (ADRD) through the R01 Clinical Trial Optional grant program. This initiative aims to support interdisciplinary research that addresses critical issues surrounding AD, which currently affects over 6 million Americans and is expected to rise significantly in the coming years. The funding is intended to promote innovative investigations that align with priorities established during NIH Alzheimer’s Disease Research Summits, with no specific budget limits but requiring proposals to reflect actual project needs. Interested applicants, including various educational institutions and nonprofit organizations, must submit their applications by November 12, 2024, and can direct inquiries to the NIH OER Webmaster at OERWebmaster03@od.nih.gov. For further details, applicants can refer to the full announcement available at http://grants.nih.gov/grants/guide/pa-files/PAR-22-093.html.