Optimization of Genome Editing Therapeutics for Alzheimer's Disease-Related Dementias (ADRD) (U01 - Clinical Trials Not Allowed)
ID: 356020Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $1M

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/356020

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-037.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) aimed at optimizing genome editing therapeutics for Alzheimer's Disease-Related Dementias (ADRD) through a cooperative agreement. This initiative seeks applications from multidisciplinary teams to advance promising genome editing candidates toward Investigational New Drug (IND)-enabling studies, focusing on disorders such as Frontotemporal Dementia and Lewy Body Dementia. Successful projects will be expected to deliver an optimized therapeutic candidate demonstrating bioactivity and manufacturability, with a total funding ceiling of $1 million per award, and applications are due by November 19, 2024. For further inquiries, interested parties can contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-24-037.html.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-NS-24-037-Full-Announcement.html
    RFA-NS-24-037.html
    The Department of Health and Human Services has issued a Notice of Funding Opportunity (NOFO) aimed at optimizing genome editing therapeutics for Alzheimer's Disease-Related Dementias (ADRD). This funding opportunity, led by the National Institutes of Health (NIH) and specifically the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA), is designed to advance promising genome editing candidates toward Investigational New Drug (IND)-enabling studies. The NOFO seeks applications from multidisciplinary teams focused on developing efficient and safe genome editing therapies across various ADRD disorders, including Frontotemporal Dementia and Lewy Body Dementia. Applicants are required to propose specific annual milestones and demonstrate clear scientific rationale, regulatory strategies, and collaborative frameworks. With an annual budget of up to $3 million for two potential awards, projects are expected to deliver an optimized therapeutic candidate, ready for clinical applications. The emphasis lies on interdisciplinary collaboration, data sharing, and adherence to rigorous scientific standards, ensuring robust outcomes beneficial for affected patient populations.
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