The National Institutes of Health (NIH) is offering a limited competition grant opportunity titled "Limited Competition: HEAL Initiative Resource Centers for the Pain Management Effectiveness Network (ERN) (Clinical Trial Not Allowed)." This initiative aims to renew the HEAL Pain Management Effectiveness Research Network Resource Centers, which are essential for planning, implementing, and completing large-scale multisite clinical trials focused on effective pain management strategies across various diseases and conditions. The Resource Centers will provide operational expertise, clinical coordination, data management, and recruitment support to enhance pain management research. Interested applicants must be recipients of RFA-TR-22-012, with applications peer-reviewed for merit. The estimated award date is August 2, 2027, and the project is expected to commence on September 2, 2027. For further inquiries, contact Yolanda F. Vallejo, PhD, at yolanda.vallejo@nih.gov or call 301-451-1751.

The National Center for Advancing Translational Sciences (NCATS), with NINDS, NIA, NIDCR, NCCIH, NCI, NIAMS, NHLBI, NICHD and the NIH Helping to End Addiction Long-term (HEAL) Initiative seeks to advance its mission by renewing the HEAL Pain Management Effectiveness Research Network (ERN) Resource Centers (RCs) needed for the successful planning, implementation, and completion of rigorous large-scale multisite clinical trials (CTs). CTs will expand the suite of evidence-based effective strategies and therapeutics to alleviate pain across the continuum of acute to chronic pain associated with many types of diseases and conditions, or presenting as a disease itself. The RCs will continue the provision of CT operational expertise, clinical coordination and safety monitoring, data coordination and biostatistical resources, and recruitment and retention support as well as access to additional clinical recruitment sites for CTs with a shared common theme of improving pain management. RCs work within the broad consortium of NCATS Clinical and Translational Science Awards (CTSA) hubs that each may contain multiple clinical sites at different institutions, to implement studies.Grant authorities that allow NCATS and HEAL to forecast this opportunity are 42 U.S.C 241, 284, and 247d.This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.

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