The National Institutes of Health (NIH) is announcing a funding opportunity for the HEAL Initiative: Pain Management Effectiveness Research Network, specifically for Clinical Trial Planning and Implementation through a Cooperative Agreement (UG3/UH3). This initiative aims to conduct large-scale, multisite clinical trials that will evaluate the efficacy of interventions designed to reduce opioid use and improve pain management across various conditions, thereby enhancing functional outcomes for patients suffering from acute to chronic pain. The program is critical in expanding evidence-based therapeutic options for pain relief, benefiting patients and their families. Interested applicants, including various eligible entities such as tribal governments and community organizations, are encouraged to prepare for this opportunity, with applications expected to be solicited starting October 15, 2025, and closing on January 5, 2026. For further inquiries, potential applicants can contact Dr. Yolanda F. Vallejo at 301-451-1751 or via email at Yolanda.Vallejo@nih.gov.