The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Developing Novel Theory and Methods for Understanding the Genetic Architecture of Complex Human Traits" (PAR-25-255). This initiative aims to support interdisciplinary research that enhances the understanding of how genetic and non-genetic factors contribute to complex human traits, encouraging applicants to develop innovative theories and models while utilizing large-scale publicly accessible datasets. The funding opportunity is not open to clinical trials and allows for applications of up to five years, with a focus on rigorous scientific design and inclusivity through a Plan for Enhancing Diverse Perspectives (PEDP). Interested applicants should note that the open submission date begins on January 5, 2025, with various deadlines extending through 2026, and can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.