The National Institutes of Health (NIH) is preparing to publish a Funding Opportunity Announcement (FOA) for the Blueprint MedTech: Prototype Developer program, aimed at supporting the development of human-grade medical device prototypes. This initiative will facilitate projects that encompass product definition and development activities, including needs assessment, product design, prototype development, and bench testing, ultimately preparing for first-in-human testing through subsequent FOAs. The FOA is expected to be published in Summer 2021, with applications due in Fall 2021, and interested applicants can reach out to Michael Wolfson, Ph.D., at Blueprint-MedTech@nih.gov or by phone at 301-451-6987 for further information. There is no cost-sharing or matching requirement for this cooperative agreement, and the opportunity is categorized as discretionary funding for eligible applicants.