Molecular and Neural Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders

The National Institutes of Health (NIH) is offering a grant opportunity titled "Molecular and Neural Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders," aimed at encouraging basic research on Non-Invasive Brain Stimulation (NIBS) techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). The objective is to elucidate the molecular, cellular, and circuit-level changes induced by NIBS protocols and to identify the mechanisms by which these techniques produce therapeutic effects in treating substance use disorders. This research is crucial as it seeks to optimize treatment parameters for addiction therapies, with an estimated total program funding of $3 million and an expected four awards to be made. Interested applicants, particularly small businesses with expertise in neuromodulation and addiction, should prepare for the application process, with the estimated synopsis post date set for March 5, 2026, and the estimated award date on April 1, 2027. For further inquiries, contact Subramaniam Ananthan, Ph.D., at sam.ananthan@nih.gov or call 301-435-2199.