The Agency for International Development (USAID) is seeking participants to collaborate on creating, piloting, and scaling innovative research and development interventions utilizing innovative health practices. The goal is to help reduce disease and mortality rates worldwide, particularly in low-and-middle-income countries (LMICs). USAID is inviting organizations and companies to submit an Expression of Interest (EOI) to generate novel tools and approaches that accelerate and sustain improved health outcomes in LMICs. The agency aims to foster co-creation, co-design, and co-investment to create high-quality partnerships with efficiency in time and resources. This opportunity welcomes collaboration from local partners in LMICs, including the private sector and faith-based organizations, to address health challenges. The funding instrument type is a Cooperative Agreement, and there is no cost sharing or matching requirement. The grant has a total award ceiling and floor of $1,000,000,000, and it is expected to result in three awards. The close date for submissions is February 20, 2028. For more information, contact Sharon D Davis at shdavis@usaid.gov or 202-567-4755.