The PROPEL Annual Program Statement (APS) aims to promote results and outcomes through policy and economic levers for global health initiatives. The APS was posted on December 7, 2021, and is open for a period of ten years, with a funding ceiling of $180 million allocated primarily over four initial rounds. The document clarifies several inquiries regarding the timeline, funding distribution, requirements for concept notes, and coordination with existing USAID initiatives. Specific details about funding allocation will be provided in each round's individual documentation, and all Rounds are expected to incorporate co-creation strategies with local partners. Key topics include the inability to specify future funding details at this moment, the necessity to monitor Grants.gov for updates on round specifics, the integration of multiple sectors in health initiatives, and potential collaboration with the Bureau for Humanitarian Assistance in fragile contexts. The Rounds aim to enhance partnerships and expand access to support for new local partners while ensuring alignment with ongoing USAID projects. Overall, the APS serves as a framework to enhance health outcomes through coordinated efforts and sustainable partnerships over a decade-long period.