The National Institutes of Health (NIH) through the National Institute on Drug Abuse (NIDA) has released a funding opportunity announcement for the P50 Research Center of Excellence Grant Program. This initiative aims to support multidisciplinary research on substance use and addiction, including its intersection with HIV. The centers are expected to foster innovative science, mentor new investigators, and serve as national resources to enhance educational outreach. Applications are invited from various eligible organizations, including higher education institutions, nonprofits, and government entities, with budgets not exceeding $10 million for a maximum project period of five years. Key submission dates start on August 25, 2023, with deadlines for application submissions occurring periodically up to September 25, 2025. Applicants must adhere to strict guidelines and include a Plan for Enhancing Diverse Perspectives to ensure inclusivity and effectiveness in research. Each center should exhibit scientific innovation, coordination among research projects, and potential to become a valuable resource in the substance use research community, ultimately influencing methods and practices within the field.