The National Institutes of Health (NIH) is offering a Notice of Funding Opportunity (NOFO) for the renewal of the MACS/WIHS Combined Cohort Study (MWCCS), aimed at funding up to 13 Clinical Research Sites (CRS) for a six-year period from 2026 to 2032. This initiative focuses on continuing research into the health determinants affecting middle-aged and older adults living with HIV, utilizing a populomics approach to address health disparities and improve quality of life for these populations. The funding opportunity is part of a broader NIH commitment to HIV research, with an anticipated investment of approximately $34.17 million, and applications are due by May 2, 2025. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.