Limited Competition: Clinical Research Sites (CRS) for the MACS/WIHS Combined Cohort Study (MWCCS) (U01 Clinical Trial Not Allowed)
ID: 358275Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $2M

Eligible Applicants

Private Institutions of Higher Education

Funding Category

Income Security and Social Services

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes
Timeline
    Description

    The National Institutes of Health (NIH) is offering a Notice of Funding Opportunity (NOFO) for the renewal of the MACS/WIHS Combined Cohort Study (MWCCS), aimed at funding up to 13 Clinical Research Sites (CRS) for a six-year period from 2026 to 2032. This initiative focuses on continuing research into the health determinants affecting middle-aged and older adults living with HIV, utilizing a populomics approach to address health disparities and improve quality of life for these populations. The funding opportunity is part of a broader NIH commitment to HIV research, with an anticipated investment of approximately $34.17 million, and applications are due by May 2, 2025. Interested applicants can find more information and contact NIH Grants Information at grantsinfo@nih.gov for inquiries.

    Point(s) of Contact
    Files
    Title
    Posted
    The National Institutes of Health (NIH) is issuing a Notice of Funding Opportunity (NOFO) for the renewal of the MACS/WIHS Combined Cohort Study (MWCCS) to continue research on individuals living with HIV. This initiative aims to fund up to 13 Clinical Research Sites (CRS) for a six-year period (2026-2032), emphasizing a populomics approach to study health determinants influencing the health and quality of life of middle-aged and older adults with HIV. The MWCCS seeks applications from organizations previously supported under RFA-HL-19-008 and intends to address health disparities in minority populations affected by HIV. The renewal aligns with broader NIH initiatives on HIV research, focusing on pivotal areas such as comorbidities, mental health, and access to healthcare for individuals living with HIV. The funding source anticipates an investment of approximately $34.17 million across various NIH components and emphasizes community engagement, participant retention, and integration of diverse research methods. Applications must uphold rigorous adherence to specified operational and investigational aims, ensuring the scientific integrity of the study. By fostering collaborative research efforts, this NOFO aims to generate high-quality data that informs effective health interventions and policies for HIV populations in the U.S.
    Similar Opportunities
    Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging," aimed at exploring the intersection of HIV and aging. This initiative seeks to enhance understanding of the biological, clinical, and socio-behavioral aspects of aging in the context of HIV infection, while also improving strategies for testing, prevention, and treatment of HIV-related health complications. Given the increasing number of older adults living with HIV, this research is crucial for addressing public health challenges and improving healthcare delivery across diverse populations. The funding supports exploratory research under the R21 mechanism, with a maximum budget of $275,000 for two years, and applications are due between May 2025 and January 2027. For more information, interested applicants can contact NIH Grants Information at grantsinfo@nih.gov or visit the opportunity's webpage at https://grants.nih.gov/grants/guide/pa-files/PAR-25-355.html.
    Interventions to Address HIV-Related Comorbidities among Highly Affected Populations Experiencing Health Disparities (R01 - Clinical Trial Required)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Interventions to Address HIV-Related Comorbidities among Highly Affected Populations Experiencing Health Disparities (R01 - Clinical Trial Required)." This initiative aims to support multilevel and multidisciplinary intervention research focused on improving the quality of life and promoting successful aging among individuals living with HIV, particularly those from racial and ethnic minority groups and lower socioeconomic backgrounds. The funding, which ranges from $5-6 million to support approximately 5-6 awards, will provide a maximum budget of $750,000 annually over five years for projects that address social determinants of health and involve community engagement. Interested applicants can find more details and guidelines on the NIH website, with the application process opening on November 11, 2023, and a submission deadline of December 12, 2025. For inquiries, contact NIH Grants Information at grantsinfo@nih.gov.
    Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities (R01 - Clinical Trials Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a funding opportunity titled "Elucidating Mechanisms Associated with HIV Related Co-Morbidities in Populations Experiencing Health Disparities." This initiative aims to support research that investigates the underlying mechanisms contributing to health disparities in HIV and aging, particularly focusing on how multiple comorbidities affect health outcomes and quality of life among individuals from marginalized populations. The program emphasizes a multidisciplinary approach and encourages engagement with community stakeholders to enhance the relevance of the research. Approximately $3 million is available for four awards and $1.5 million for two additional awards for fiscal year 2024, with a project duration of up to five years. Interested applicants can find more information and guidelines at the NIH Grants website and should direct inquiries to grantsinfo@nih.gov. The application deadline is set for January 7, 2026.
    Centers for AIDS Research (CFAR)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a federal grant opportunity titled "Centers for AIDS Research (CFAR)" aimed at advancing HIV/AIDS research through the establishment and support of a national network of CFARs. This initiative seeks to foster multidisciplinary collaborations and provide infrastructure that enhances the efficiency and effectiveness of HIV/AIDS research, particularly by supporting early-career investigators and funding innovative pilot studies. With an estimated total program funding of $4,202,000 and an expected six awards, interested applicants, including various organizations and non-domestic entities, should note that the application period is open until August 19, 2026, with awards anticipated to be made by March 1, 2027. For further inquiries, applicants can contact the CFAR Program at CFARprogram@mail.nih.gov or call 240-459-2852.
    Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity for multidisciplinary research on HIV/AIDS and aging through the R21 Exploratory/Developmental Research Grant program. This initiative invites applications that aim to enhance the understanding of the biological, clinical, and socio-behavioral aspects of aging in the context of HIV infection, with specific objectives to improve prevention, testing, treatment strategies, and management of HIV-related health issues in diverse populations, particularly older adults aged 70 and above. The grant provides funding of up to $275,000 for a two-year period, with key submission dates starting April 4, 2024, and a closing date for applications set for January 7, 2027. Interested applicants can find more information and guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov for further inquiries.
    Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging (R01 Clinical Trial Optional)" aimed at enhancing research on the intersection of HIV and aging. The program seeks applications that focus on improving the understanding of biological, clinical, and socio-behavioral aspects of aging in the context of HIV infection, as well as developing better methods for testing, preventing, and managing HIV-related health issues among older populations. This initiative is particularly significant given the projected increase in the prevalence of HIV among older adults, which is expected to rise from 53% to over 70% by 2030, highlighting the urgent need to address the complex challenges associated with aging and HIV. Interested applicants can submit proposals until January 7, 2027, with no budget limits as long as they align with project needs; for further inquiries, contact NIH Grants Information at grantsinfo@nih.gov or visit the additional information link at https://grants.nih.gov/grants/guide/pa-files/PAR-25-354.html.
    Implementation Science to End the HIV Epidemic
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a federal grant opportunity titled "Implementation Science to End the HIV Epidemic," aimed at advancing efforts to combat HIV through innovative research-community collaborations. The initiative seeks projects that will develop and evaluate strategies for HIV prevention, diagnosis, treatment, and outbreak response, particularly in communities disproportionately affected by the epidemic. This funding, totaling an estimated $7 million, will support approximately 10 awards, with applications open to a diverse range of eligible entities, including tribal governments, federal agencies, and community-based organizations. Interested applicants should note that the estimated synopsis close date is April 17, 2026, and the anticipated award date is December 1, 2026; for further inquiries, contact Rebecca Mandt, Ph.D., at rebecca.mandt@nih.gov or call 301-435-7695.
    Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)
    National Institutes of Health
    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) for the Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research, aimed at providing ongoing support for breeding colonies of Specific Pathogen Free (SPF) macaques essential for HIV/AIDS research. The funding will facilitate the breeding, maintenance, and allocation of these macaques to qualified researchers, ensuring rigorous health and genetic monitoring to mitigate risks associated with certain viruses that could affect research outcomes. These colonies play a critical role in advancing studies related to vaccine development and co-infection, underscoring their importance in the fight against HIV/AIDS. Interested applicants, specifically public and state-controlled institutions of higher education, must submit their proposals by January 7, 2027, and can find further details and application guidelines at the NIH grants website or contact NIH Grants Information at grantsinfo@nih.gov.
    Notice of Intent to Publish a Funding Opportunity Announcement for HIV Pediatric, Adolescent and Maternal Clinical Trials
    National Institutes of Health
    The National Institutes of Health (NIH) plans to publish a Notice of Funding Opportunity (NOFO) for research focused on high-priority HIV studies targeting infants, children, adolescents, young adults, and maternal populations. This initiative aims to establish an HIV clinical trials network dedicated to these demographics, fostering innovative and collaborative clinical trials to address significant research areas in HIV and related health issues. The estimated total program funding is $30 million, with two awards anticipated, and potential applicants are encouraged to begin forming collaborations and developing proposals ahead of the expected synopsis posting on November 21, 2025. For further inquiries, interested parties may contact Dr. Sonia Lee at Sonia.lee@nih.gov or by phone at 301-594-4783.
    High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)
    National Institutes of Health
    The National Institutes of Health (NIH) is offering a funding opportunity titled "High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)" aimed at supporting innovative research that addresses the intersection of HIV and substance use. This initiative invites applications from individual researchers and research teams to develop projects that can lead to new prevention, treatment, and care strategies for individuals affected by both conditions, with a requirement for a detailed research plan and preliminary data. A total budget of $3.0 million is available for funding one to two awards, with individual project budgets capped at $1.5 million per fiscal year, and applications are due by February 12, 2027. Interested applicants can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries and are encouraged to consult with NIDA program staff early in the application process.