The National Institutes of Health (NIH) has announced a funding opportunity for R21 grants aimed at promoting innovative research in the pathogenesis of Treponema pallidum, the bacterium responsible for syphilis. The program, identified by grant number RFA-AI-24-071, seeks to support basic and exploratory research projects that enhance understanding of T. pallidum biology, particularly in areas such as immune evasion and congenital syphilis models, with a total funding of $2 million planned for fiscal year 2025 to support 4-6 awards. This initiative is crucial in addressing the rising rates of syphilis infections and the challenges associated with treatment. Applications are due by November 5, 2024, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.