Limited Competition: Specific Pathogen Free Macaque Colonies (U42 Clinical Trial Not Allowed)

Active
No
Status
Posted
Published Date
January 9th, 2024
Close Date
January 25th, 2024
Opportunity No.
PAR-24-078

Agency

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Public and State Controlled Institutions of Higher Education

Funding Category

Health

Funding Instrument

Cooperative Agreement

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Summary

The National Institutes of Health (NIH) has posted a grant opportunity titled "Limited Competition: Specific Pathogen Free Macaque Colonies (U42 Clinical Trial Not Allowed)". This grant aims to provide continuing support for specific pathogen-free (SPF) macaque colonies that support Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. The breeding colonies of SPF macaques are essential for sustaining appropriate research related to HIV/AIDS. These macaques are genetically characterized for major histocompatibility complex (MHC) class I types, which have significant effects on macaque immune responses to Simian Immunodeficiency Virus (SIV) and human immune responses to HIV. The grant does not require cost sharing or matching and is categorized under health funding activities. Public and State Controlled Institutions of Higher Education are eligible to apply. For more information, please visit the grant opportunity page.

Description

The purpose of this Notice of Funding Opportunity (NOFO) is to provide continuing support for specific pathogen-free (SPF) macaque colonies previously funded under the auspices of PAR-21-089 and PAR-18-669 that support Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) research. Breeding colonies are essential to sustain appropriate SPF macaques for research related to HIV/AIDS. Pedigree SPF macaques are free of certain viruses, which may confound the results of HIV/AIDS-related investigations or present a risk to the personnel who care for the animals. The SPF macaques are genetically characterized for major histocompatibility complex (MHC) class I types, because MHC class I genotypes have large effects on macaque immune responses to Simian Immunodeficiency Virus (SIV) that can induce AIDS in nonhuman primates (NHPs) and on human immune responses to HIV.

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