The National Institutes of Health (NIH) is preparing to publish a Notice of Funding Opportunity (NOFO) for the RNA Modifications Driving Oncogenesis (RNAMoDO) Initiative, aimed at advancing mechanistic research on RNA modifications that contribute to cancer development. This initiative seeks collaborative research projects that explore the role of mRNA, tRNA, and rRNA modifications in translational reprogramming during tumor initiation and progression, emphasizing the need for interdisciplinary expertise to address the complex interactions of these modifications. The estimated total program funding is $4.9 million, with an award ceiling of $650,000 for up to five projects, and the NOFO is expected to be published in early Fall 2024, with applications due in November 2024. Interested applicants are encouraged to prepare collaborations and can find additional information through the NCI Board of Scientific Advisors presentation linked in the opportunity overview.