Functional Target Validation for Alzheimer's Disease-Related Dementias (R61/R33 Clinical Trial Not Allowed)
ID: 354648Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/354648

Additional Information

http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-011.html
Timeline
    Description

    The National Institutes of Health (NIH) has announced a Notice of Funding Opportunity (NOFO) titled "Functional Target Validation for Alzheimer's Disease-Related Dementias (ADRD)," aimed at supporting research that validates new therapeutic target candidates for various forms of dementia, including frontotemporal degeneration and Lewy body dementias. The initiative is structured in two phases: the R61 phase, which lasts two years and focuses on the development of technologies and models for target modulation, and the R33 phase, which emphasizes rigorous validation of these targets across multiple laboratories. This funding opportunity is critical for enhancing the efficacy of potential therapies for ADRD, addressing a significant public health challenge. Interested applicants can apply for a total budget of approximately $1.8 million for the R61 phase and up to $3 million for the R33 phase, with a submission deadline of November 8, 2024. For further inquiries, applicants may contact NIH Grants Information at grantsinfo@nih.gov.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    RFA-NS-25-011-Full-Announcement.html
    RFA-NS-25-011.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), has issued a Notice of Funding Opportunity (NOFO) titled "Functional Target Validation for Alzheimer's Disease-Related Dementias (ADRD)." This funding opportunity encourages applications focused on validating new therapeutic target candidates for ADRD, which includes various dementia types such as frontotemporal degeneration and Lewy body dementias. The research proposal is structured in two phases: R61, lasting two years for initial technology development, and R33, which focuses on rigorous validation across different laboratories. Applicants must demonstrate collaborative efforts and establish milestones while utilizing human tissue data for target selection. The program has a budget of approximately $1.8 million for R61 phase awards and up to $3 million for the R33 phase, permitting a maximum budget of $600,000 for R61 and $1 million for R33 applications. Eligible applicants include higher education institutions and non-profit organizations, with an emphasis on diverse participation. The deadline for submissions is November 8, 2024, and the initiative emphasizes the critical importance of target validation to enhance confidence in the efficacy of potential therapies for ADRD, ultimately addressing a pressing public health issue affecting millions globally.
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