Translational Bioinformatics and Experimental Approaches to Advance Drug Repositioning and Combination Therapy Development for Alzheimers Disease and Related Dementias (R01 Clinical Trial Not Allowed)
ID: 357943Type: Posted
Overview

Buyer

National Institutes of Health (HHS-NIH11)

Award Range

$0 - $1M

Eligible Applicants

Others

Funding Category

Health

Funding Instrument

Grant

Opportunity Category

Discretionary

Cost Sharing or Matching Requirement

Yes

Original Source

https://grants.gov/search-results-detail/357943

Additional Information

http://grants.nih.gov/grants/guide/pa-files/PAR-25-374.html
Timeline
    Description

    The National Institutes of Health (NIH) is offering a funding opportunity aimed at advancing drug repositioning and combination therapy development for Alzheimer's Disease (AD) and related dementias (ADRD). This initiative invites applications that utilize mouse models to conduct rigorous preclinical testing of FDA-approved drugs or investigational compounds, with the goal of establishing proof of concept for effective treatment strategies. Given the historical challenges in developing successful AD therapies, this program emphasizes a systematic approach and encourages collaboration between academia and industry to enhance research rigor and reproducibility. Applicants may receive up to $1 million annually, with a total funding pool of $6 million available for 4-5 awards. The application deadline is May 7, 2028, and interested parties can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries.

    Point(s) of Contact
    grantsinfo@nih.gov
    Files
    Title
    Posted
    PAR-25-374-Full-Announcement.html
    PAR-25-374.html
    The Department of Health and Human Services, through the National Institutes of Health (NIH), announces a funding opportunity for projects focused on advancing drug repositioning and combination therapy development for Alzheimer's Disease (AD) and related dementias (ADRD). The initiative invites applications that utilize computational and experimental approaches to rigorously test FDA-approved drugs or investigational compounds currently misappropriated for other conditions, aimed at demonstrating efficacy for AD/ADRD. The goal is to support in-vivo and in-vitro proof-of-concept studies to establish synergies and optimize therapeutic strategies. While drug repurposing has potential advantages like reduced development costs and timeframes, previous efforts in AD treatments have been largely unsuccessful, underlining the need for a more systematic approach. The program encourages collaborative partnerships between academia and industry, and emphasizes compliance with NIH policies for research rigor and reproducibility. Applications can receive up to $1 million annually, with a funding pool of $6 million intended for 4-5 awards. The application process has defined deadlines and submission requirements designed to ensure thorough review and compliance with open research practices, stressing the importance of data management and sharing throughout the project lifespan.
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