The National Institutes of Health (NIH) has announced a funding opportunity titled "Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)" aimed at enhancing understanding of TDP-43 pathology and its relationship with cognitive decline in various neurodegenerative diseases. This initiative seeks innovative research proposals that explore mechanistic studies comparing at least two TDP-43 proteinopathies, with a focus on Alzheimer’s Disease Related Dementias (ADRD) and related syndromes, while excluding purely epidemiological or descriptive studies. The program is part of a broader effort to address national Alzheimer’s research priorities and will provide up to $4.5 million per year for six awards over five years, with applications accepted starting May 4, 2024. Interested applicants can reach out to NIH Grants Information at grantsinfo@nih.gov for further inquiries, and the application deadline is set for October 4, 2024.