The Department of Health and Human Services, through the National Institutes of Health, has issued a Notice of Funding Opportunity (NOFO) for research into Alzheimer's Disease-Related Dementias (ADRD) with multiple co-pathologies. Funding is available under the R01 research project grant program, supporting investigations that explore how the interactions between at least two ADRD pathologies aggravate disease progression and phenotypic outcomes, including cognitive and functional impairments. Applications are encouraged to adopt various model systems to investigate cellular and molecular mechanisms implicated in ADRD. The program is particularly focused on advancing health equity by considering diverse human populations in research samples. Applications must comply with specific NIH guidelines, cannot propose clinical trials, and should not overlap significantly with other submissions. An estimated total budget of up to $4.5 million per year is allocated for funding, with a maximum project period of five years. The application process stipulates detailed submissions through Grants.gov and eRA Commons. Key dates include an opening date for submissions on May 4, 2024, and an expiration date of October 5, 2024. This initiative aligns with national efforts to develop effective treatments for ADRD, aiming to significantly advance understanding and potential treatment pathways.